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Based on the calcium dependence of calcineurin (CaN), calcium further serves as a second messenger to drive the CaN/nuclear factor of activated T cells (NFAT) pathway, participating in osteoblast proliferation, differentiation, and apoptosis (96)

In some embodiments, the otic formulation or composition comprises about 0.01% to about 1% by weight of the viscosity modulating agent(s)